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50th ERA-EDTA Congress

 

May 18-21 2013 Istanbul
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Discussion forum - 50th ERA-EDTA Congress
    Topic - Diabetes - experimental models

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Poster: 266
Visits: 36
Title: LONG-TERM STUDY OF ERYTHROPOIETIN, LOSARTAN, AND COMBINATION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
Authors: Rehab Ashour , Rehab H Ashour,1 Abd El-Motaal M Fouda,1 Mohamed A Saad,1 Farida M El-Banna,1 Fatma A Moustafa,2 Manal I Fouda.3
Centre: Faculty of Medicine, Mansoura University, Clinical Pharmacology Department

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LONG-TERM STUDY OF ERYTHROPOIETIN, LOSARTAN, AND COMBINATION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Rehab Ashour
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Subspeciality
Reg: 4/25/2013 10:53:00 AM
Comment# 1
Recombinant human erythropoietin (rHuEPO) has emerged as a new renoprotective agent against various acute kidney injuries. Experience with rHuEPO in chronic kidney injuries is so far limited and conflicting results were obtained. In the present study, we addressed to evaluate the long-term renal effects of rHuEPO in diabetic nephropathy (DN) of rats in relation to novel hypoxia theory and endogenous EPO secretion. We compared rHuEPO to a standard drug, losartan (LSR), and the possibility of add-on therapy was also tested.

Comment added on 4/25/2013 10:53:00 AM 
     
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